2024 Amiodarone toxicity blue skin - blag0y.ru
WEBNov 21, 2014 · Amiodarone-induced blue-gray facial pigmentation associated with diffuse erythema in 81-year-old patient treated with amiodarone 200 mg daily for 15 years due to paroxysmal atrial fibrillation. The clinical manifestation is indicative of a phototoxic reaction.WEBJun 9, 2023 · Blue-gray cutaneous discoloration, also known as blue man syndrome, is an undesirable and unusual side-effect of chronic amiodarone therapy in less than 3% of patients. Case presentation.WEBAmiodarone is known to cause cutaneous and systemic side effects. The most common cutaneous side effect is photosensitivity. Blue–gray discoloration occurs on body areas when exposed to sunlight. The disappearance of amiodarone-related skin discoloration may occur within months or years.WEBJun 9, 2023 · Blue-gray cutaneous discoloration, also known as blue man syndrome, is an undesirable and unusual side-effect of chronic amiodarone therapy in less than 3% of patients. This report presents a 51-year-old Caucasian man treated for the past 3 years with amiodarone and implantable cardioverter defibrillators due to his ventricular ...WEBNov 1, 2022 · Long-term use of amiodarone is associated with various toxic side effects involving the cornea, thyroid, lungs, liver, skin and other systems. Blue-gray skin pigmentation is one of the rarely reported side effects …WEBWithin 1 month after discontinuation of amiodarone the patient’s blue-gray discoloration vanished, confirming the diagnosis of amiodarone-induced pigmentation (ceruloderma). This typical appearance is due to deposition of melanin and lipofuscin in the dermis and occurs in 1% to 3% of patients on chronic amiodarone therapy, preferentially ...WEBJan 15, 2020 · Abstract. An 81-year-old man with atrial fibrillation who was being treated with amiodarone presented to the ED after a fall. Physical examination revealed blue and gray discoloration of his...WEBBlue man syndrome is thought to stem from the deposition of lysosomal membrane-bound dense bodies, similar to lipofuscin, in the dermis of patients on chronic amiodarone therapy. We present the case of a 77-year-old male who presented to us post-cardiac arrest secondary to hyperkalemia of 7.0.WEBDec 16, 2022 · Although photosensitivity reactions due to amiodarone are common, blue-gray skin pigmentation is one of the rarely reported side effects and is seen in 1% to 3% of patients. It is rarely seen today, as patients are educated to take precautions to avoid exposure to direct sunlight.WEBDec 1, 2018 · We describe a relatively rare adverse effect of amiodarone in our case report of a 61-year-old man, who was electively admitted for implanted cardioverter defibrillator upgrade. Pronounced grey skin discolouration led …WEBThe lesions were in the form of blue-gray dis-colorations in the skin of the nose and cheeks. After admission, amiodarone was discontinued and replaced with mexiletine cap 200 mg thrice daily due to skin lesions. ICD analysis revealed a VT episode ter-minated by a 20 J shock that lasted 38 min.WEBJul 24, 2023 · While long-term contemporary use of amiodarone has generally been at lower doses (200 to 300 mg/day) than were historically used, even low doses may be associated with significant adverse effects, particularly pulmonary, thyroid, cardiac, skin, and ocular toxicities.Missing: blue skinMust include: blue skinWEBAmiodarone is increasingly used in cardiology due to convenient dosing, low frequency of pro-arrhythmic effects, and good short term tolerance without significant hypotension. However, chronic use is associated with multisystem toxic side effects.WEBThe present review outlines our current understanding of the epidemiology and risk factors for amiodarone induced-blue man syndrome, the pathophysiology of this condition and currently available management options.WEBFeb 8, 2016 · Amiodarone‐induced blue‐gray skin pigmentation is most often reported to occur following long‐term treatment in elderly patients with a predominance of male patients. The exact pathomechanism of blue‐gray skin syndrome is still controversial.WEBJul 30, 2010 · Amiodarone-related phototoxicity induces blue–gray skin hyperpigmentation of predominantly sunexposed areas. 1 It develops in <10% of patients, preferentially affecting men. 2 It was mainly observed after an average of 20 months of continuous amiodarone treatment and a minimal cumulative dose of 160 g. 3 …WEBBlue man syndrome is thought to stem from the deposition of lysosomal membrane-bound dense bodies, similar to lipofuscin, in the dermis of patients on chronic amiodarone therapy. We present the case of a 77-year-old male who presented to us post-cardiac arrest secondary to hyperkalemia of 7.0.Missing: blue skinMust include: blue skinWEBAmiodarone. Blue-grey pigmentation in sun-exposed areas (face and hands). Photosensitivity occurs in 30–57% of patients, while 1–10% show skin pigmentation. Skin pigmentation is reversible, but it may take up to one year for complete resolution after the drug has been stopped.WEBNov 1, 2022 · Long-term use of amiodarone is associated with various toxic side effects involving the cornea, thyroid, lungs, liver, skin and other systems. Blue-gray skin pigmentation is one of the rarely reported side effects …WEBNov 30, 2021 · Other adverse effects from amiodarone include photosensitivity, blue-gray discoloration of the skin, thyroid dysfunction, corneal deposits, abnormal liver function tests, and bone marrow suppression [ 2 ]. The types, pathogenesis, risk factors, diagnosis, and treatment of amiodarone pulmonary toxicity will be reviewed here.WEBFeb 8, 2016 · Amiodarone-induced blue-gray skin pigmentation is most often reported to occur following long-term treatment in elderly patients with a predominance of male patients. The exact pathomechanism of blue-gray skin syndrome is still controversial. Several different theories are discussed in literature.WEBFeb 1, 2023 · Blue man syndrome is a condition that presents with bluish gray hyperpigmentation of the skin due to long term administration of amiodarone. This is a rare side effects of the drug amiodarone.WEBDermatologic side effects include photosensitivity (24%–57%) and blue-gray skin discoloration (1%–7%). The mechanism of the reaction seems to be related to the active metabolites generated by UV radiation and oxygen free radicals.WEBAmiODAROne 150mg/3mL injection, 5mg/ml suspension(WCH)* ... fever, skin pigmentation (blue-grey), corneal microdeposits, neurotoxicity (tremor, ataxia, paraesthesia, peripheral neuropathy, limb weakness), pulmonary toxicity, bradycardia, hypotension (IV) Infrequent . Atrioventricular block, arrhythmias (new or exacerbated) Rare .
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